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Caroline Whitbeck Elmer G. Beamer-Hubert H. Schneider Emerita Professor in Ethics Case Western Reserve University Case Western Reserve University More Posts
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A Cognitive Enhancing Drug Requiring Blood Draws
Secondary Title A Cognitive Enhancing Drug Requiring Blood Draws

Added08/18/2006

Author(s) Stephen G. Post

A scenario about research in which blood is drawn from patients with dementia who cannot understand the reason why.

Author(s): Stephen Post, Ph.D.

According to the cholinergic hypothesis, lowered levels of the neurotransmitter acetylcholine are implicated in AD. Researchers want to interrupt the action of the molecule that breaks down acetylcholine (acetylcholinesterase). A new drug intended to achieve this goal is being studied with AD patients in the early and moderate stages of the disease. No other drugs are available. This drug is associated with living toxicity in as many as half of the patients/subjects, all of whom must be monitored with a bi-weekly blood draw.

For those patients/subjects who lack insight into the purpose of the blood draw, reaction to the sight of the needle can be emotionally acute and cause considerable agitation. A family caregiver accompanies the patient/subject to the clinic in order to provide comfort, assistance, and if necessary, persuasion in such cases of initial dissent.

Family surrogates can provide informed consent in this study; patients/subjects need not be competent to consent because the study has limited risks that are being monitored and provides potential therapeutic benefits for the participants. (See key issues in dementia research.) Family surrogates are very hopeful about this first AD anti-dementia drug, although there is of yet no evidence that it is effective.

Why might the subject's informed consent be valuable in this kind of study?

How should the burdens and benefits of this study for the subject/patient be described in the consent form?

How seriously should the patient/subject's dissent be taken? To what extent should the manipulation of dissenting be allowed?

Would you characterize against the framework of risk and therapeutic benefit?

From Discussion Scenarios for Group Mentoring in Responsible Research
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Contributor(s) Caroline Whitbeck
Notes Caroline Whitbeck introduced methods and modules for discussing numerous issues in responsible conduct of research at a Sigma Xi Forum in 2000. Partial funding for the development of this material came from an NIH grant. You can find the entire sequence on the OEC at http://www.onlineethics.org/Resources/TeachingTools/Modules/19237.aspx. Some information in these historical modules may be out-of-date; for instance, there may be a new edition of the professional society’s code that is referred to in an item. If you have suggestions for updates, please contact the OEC.
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Rights For more information on permissions to use this material please see: http://onlineethics.org/permissions.aspx
Year 2000
Publisher provided Keywords BIOLOGY CHEMISTRY Informed Consent MEDICINE
Publisher National Academy of Engineering, Online Ethics Center
Language English
  • Using Case Studies Bibliography

    Added03/26/2010

    This bibliography includes examples of different ways instructors have used case studies to introduce ethical topics to their students and resources for finding cases and incorporating them into the classroom.

    Author(s) Kelly Laas
    Year 2016
  • Added08/23/2006

    In this essay, Dr. Whitbeck outlines an 'agent-centered' approach to learning ethics. The central aim is to prepare students to act wisely and responsibly when faced with moral problems. She provides a number of examples and cases with descriptions of questions and directions for promoting student participation and stimulating thought and discussion.

    Year 1995
Cite this page: "A Cognitive Enhancing Drug Requiring Blood Draws" Online Ethics Center for Engineering 8/18/2006 OEC Accessed: Tuesday, September 27, 2016 <www.onlineethics.org/Resources/TeachingTools/Modules/19237/resethpages/cogAD.aspx>